Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

Thomas Münzel, Hassan Sayegh, Bruce Α. Freeman et al. · Journal of Clinical Investigation · 1995 · 655 citations · Full text

Life Sciences, Pharmacology, Physiology +15

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Thomas Münzel, Stephan Kurz, Sanjay Rajagopalan et al. · Journal of Clinical Investigation · 1996 · 312 citations · Full text

Medicine, Pharmacology, Physiology +14

Nonatheromatous Ischemic Heart Disease following Withdrawal from Chronic Industrial Nitroglycerin Exposure

Ramon L. Lange, Michael S. Reid, Donald D. Tresch et al. · Circulation · 1972 · 263 citations · Full text

Medicine, Cardiology, Internal Medicine +14

Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability

Thomas Münzel, Huige Li, Hanke Mollnau et al. · Circulation Research · 2000 · 236 citations · Full text

Life Sciences, Pharmacology, Physiology +13

Effect of Intervals between Doses on the Development of Tolerance to Isosorbide Dinitrate

John O. Parker, Bernice Farrell, Karen A Lahey et al. · New England Journal of Medicine · 1987 · 220 citations

Medicine, Pharmacology, Pharmacotherapy +11