Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats

Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

Philip S. Portoghese, A. W. Lipkowski, A.E. Takemori · Life Sciences · 1987 · 533 citations

Medicine, Medicinal Chemistry, Pharmacology +10

β-Endorphin Is Associated with Overeating in Genetically Obese Mice ( <i>ob</i> / <i>ob</i> ) and Rats ( <i>fa</i> / <i>fa</i> )

David L. Margules, Beatriz Moisset, Michael J. Lewis et al. · Science · 1978 · 475 citations

Medicine, Endocrinology, Pharmacology +17

Opioid modulation of appetite

John E. Morley, Allen S. Levine, G.K.W. Yim et al. · Neuroscience & Biobehavioral Reviews · 1983 · 454 citations

Medicine, Neuroscience, Pharmacology +11

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

Frank Porreca, Henry I. Mosberg, R. P. Hurst et al. · Journal of Pharmacology and Experimental Therapeutics · 1984 · 430 citations

Medicine, Pharmacology, Molecular Pharmacology +16

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities

Philip S. Portoghese, Dennis L. Larson, Lawrence M. Sayre et al. · Journal of Medicinal Chemistry · 1980 · 288 citations

Medicine, Medicinal Chemistry, Pharmacology +15