Concepedia

The Effects of Lidocaine on Nitric Oxide Production from an Activated Murine Macrophage Cell Line

Makoto Shiga, Kahoru Nishina, K Mikawa, Hidefumi Obara

Anesthesia & Analgesia · 2001 · 32 citations · 25 references

DOI

Abstract

Lidocaine dose-dependently inhibited nitric oxide production by activated macrophages, presumably at levels after transcription. The attenuating effect of lidocaine on organ injuries previously reported may be explained by the ability of the drug to suppress this inflammatory mediator.

References

25

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251K citations

, , +8

Interaction of Neuronal Nitric-oxide Synthase with Caveolin-3 in Skeletal Muscle

Virginia J. Venema, Hong Ju, Rong Zou et al. · Journal of Biological Chemistry · 1997 · 255 citations · Full text

Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites

R. R. MacGregor, RE Thorner, D. M. Wright · Blood · 1980 · 203 citations · Full text

Arginase II Downregulates Nitric Oxide (NO) Production and Prevents NO-mediated Apoptosis in Murine Macrophage-derived RAW 264.7 Cells

Tomomi Gotoh, Masataka Mori · The Journal of Cell Biology · 1999 · 197 citations · Full text

, , +16

Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines.

Makoto Koide, Yoshihiro Kawahara, Ichiro Nakayama et al. · Journal of Biological Chemistry · 1993 · 187 citations · Full text

, , +20