Syntheses of core chain trisaccharides related to human blood group antigenic determinants

Abstract

Trisaccharides related to the core chain of human blood group determinants were synthesized by way of the phthalimido-chloride method; namely, β-D-Galp-(1 → 3)-β-D-GlcNAcp-(1 → 6)-D-Galp (3), β-D-Galp-(1 → 3)-β-D-GlcNAcp-(1 → 3)-D-Galp (5), β-D-Galp-(1 → 4)-β-D-GlcNAcp-(1 → 6)-D-Galp (4), and β-D-Galp-(1 → 4)-β-D-GlcNAcp-(1 → 3)-D-Galp (6). The syntheses of the 8-methoxy-carbonyloctyl β-glycosides of these trisaccharides are also reported.