2011 · 14 citations · 10 references
Medical ElectronicsEngineeringSynthetic CircuitBiomedical EngineeringBioanalysisMetabolic EngineeringAnalytical ChemistryClinical ChemistryHuman MetabolismImplantable SensorBiochemistryMetabolomicsBioinstrumentationPharmacologyCircuit DesignBioelectronicsCmos CircuitSynthetic BiologyElectrophysiologyElectroanalytical SensorMetabolic ProfilingMedicineDrug Analysis
Monitoring human metabolism is of crucial importance for personalized medicine. The aim of the present work is to design an interface circuit to realize an integrated platform for the detection of endogenous and exogenous metabolites for implantable applications. Cyclic voltammetry and chronoamperometry are the most common methods for metabolite detection. We propose a CMOS circuit to implement these two methods in a multi-target detection scheme.
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Function of an Implanted Tissue Glucose Sensor for More than 1 Year in Animals
David Gough, L. Kumosa, Timothy L. Routh et al. · Science Translational Medicine · 2010 · 176 citations · Full text