Concepedia

Effects of releasing recombinant human growth and differentiation factor-5 from poly(lactic-<i>co</i>-glycolic acid) microspheres for repair of the rat degenerated intervertebral disc

Jihong Yan, Huaimei Sun, Duo Guo, Bo Wu, Fengqing Ji, Deshan Zhou

Journal of Biomaterials Applications · 2013 · 38 citations · 23 references

DOI

Abstract

The results of this study suggest that injection of rhGDF-5 loaded in PLGA microspheres into rat tail discs may be as a promising therapy strategy to regenerate or repair the degenerative disc.

References

23

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, , +6

Fluorometric assay of DNA in cartilage explants using Hoechst 33258

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, , +11

Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres

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Preparation of microspheres by the solvent evaporation technique

Patrick B. O’Donnell, James W. McGinity · Advanced Drug Delivery Reviews · 1997 · 794 citations

, , +4

A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration

Koichi Masuda, Yoichi Aota, Carol Muehleman et al. · Spine · 2005 · 712 citations