Differential Expression and Activity of 11β-Hydroxysteroid Dehydrogenase in Human Placenta and Fetal Membranes from Pregnancies with Intrauterine Growth Restriction

Abstract

Reduced synthesis or activity of 11beta-HSD1 or 2 in cases of IUGR is shown in some but not in all tissues. The local mRNA expression of 11beta-HSD1 in chorion may reflect a mechanism on the post-transcriptional gene regulation to stimulate the formation of cortisone in IUGR. To provoke increasing activity with oxidase stimulators could be a future therapy in cases of IUGR.