Antimicrobial Agents and Chemotherapy · 2007 · 18 citations · 16 references
MedicineImmunologyPharmacologyImmunopharmacologyInflammationInnate ImmunityAnti-inflammatory PharmacologyInflammation PharmacologyEndotoxin-mediated DiseaseEndotoxin-mediated InflammationFosfomycin TherapyImmunomodulatory CytokinesImmunomodulatory EffectsInflammatory Response To Bacterial InfectionProinflammatory Mediators
To evaluate the effect of fosfomycin on proinflammatory cytokines, a bolus of 2 ng of bacterial lipopolysaccharide/kg of body weight was injected intravenously into healthy volunteers. After 2 h, subjects received 8 g of fosfomycin or placebo in a randomized crossover study design. The resulting concentrations of tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-6 expressed as protein and mRNA levels were almost identical with and without fosfomycin.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations
Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis
Edward Abraham, Konrad Reinhart, Steven M. Opal et al. · JAMA · 2003 · 957 citations