The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Michael B. Kastan, Qimin Zhan, Wafik S. El‐Deiry et al. · Cell · 1992 · 3.1K citations

Life Sciences, Cell Biology, Molecular Biology +12

Metal chelate affinity chromatography, a new approach to protein fractionation

Jerker Porath, Jan Carlsson, Ingmar Olsson et al. · Nature · 1975 · 2.1K citations

Life Sciences, Biochemistry, Chemistry +14

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

Chang‐Min Kim, K. Koike, Izumu Saito et al. · Nature · 1991 · 1.2K citations

Medicine, Molecular Biology, Oncology +13

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

Francis Galibert, Elisabeth Mandart, Françoise Fitoussi et al. · Nature · 1979 · 987 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

Phillip Shaw, R Bovey, Sébastien Tardy et al. · Proceedings of the National Academy of Sciences · 1992 · 859 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15