Feglymycin is an Inhibitor of the Enzymes MurA and MurC of the Peptidoglycan Biosynthesis Pathway

Abstract

Selective inhibition: Feglymycin, a natural 13-mer peptide antibiotic from Streptomyces sp. with activity against MRSA strains was tested in a one-pot assay against the enzymes MurA–F from E. coli. Dereplication revealed that feglymycin specifically inhibits the enzymes MurA and MurC. Feglymycin is therefore the first natural inhibitor of MurC. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.