Discovery of (2<i>S</i>)-1-(4-Amino-2,3,5- trimethylphenoxy)-3-{4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl}-2- propanol Dimethanesulfonate (SUN N8075):  A Dual Na⁺and Ca²⁺Channel Blocker with Antioxidant Activity

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of (2S)-1-(4-Amino-2,3,5- trimethylphenoxy)-3-{4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl}-2- propanol Dimethanesulfonate (SUN N8075): A Dual Na+ and Ca2+ Channel Blocker with Antioxidant ActivityHirokazu Annoura, Kyoko Nakanishi, Tetsuya Toba, Naohiro Takemoto, Seiichi Imajo, Atsuko Miyajima, Yoshiko Tamura-Horikawa, and Shigeki TamuraView Author Information Suntory Biomedical Research Limited, 1-1-1, Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan Cite this: J. Med. Chem. 2000, 43, 18, 3372–3376Publication Date (Web):August 19, 2000Publication History Received28 March 2000Published online19 August 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/jm000143whttps://doi.org/10.1021/jm000143wrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views526Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Ions,Mechanisms of action,Pharmacology,Receptors,Rodent models Get e-Alerts