Concepedia

Lrig2-Deficient Mice Are Protected against PDGFB-Induced Glioma

Veronica Rondahl, Camilla Holmlund, Terese Karlsson, Baofeng Wang, Mahmood Faraz, Roger Henriksson, Håkan Hedman

PLoS ONE · 2013 · 42 citations · 39 references

DOIFull text

Open access

Abstract

The phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma, and Lrig2 appeared to have important molecular and developmental functions that were distinct from those of Lrig1 and Lrig3.

References

39

Erratum to: The 2007 WHO classification of tumours of the central nervous system

David N. Louis, Hiroko Ohgaki, Otmar D. Wiestler et al. · Zurich Open Repository and Archive (University of Zurich) · 2007 · 4.5K citations

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

Chengkai Dai, Joseph Celestino, Yoshifumi Okada et al. · Genes & Development · 2001 · 704 citations · Full text

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

Anne E. Powell, Yang Wang, Yina Li et al. · Cell · 2012 · 671 citations · Full text

, , +6

PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts

Linda Schneider, Christian Clément, Stefan Cuoni Teilmann et al. · Current Biology · 2005 · 565 citations · Full text

, , +12

A constitutively active epidermal growth factor receptor cooperates with disruption of G<sub>1</sub> cell-cycle arrest pathways to induce glioma-like lesions in mice

Eric C. Holland, Wendy P. Hively, Ronald A. DePinho et al. · Genes & Development · 1998 · 557 citations · Full text

, , +21