Neuroblastoma 4S

Abstract

The data presented here suggest an important role for age as a prognostic factor. The very young NBL 4S patient (age < 4 weeks at diagnosis) was at high risk of dying of (respiratory) complications as a result of massive hepatomegaly. In contrast, disease progression to Stage 4 appears to be unrelated to age, but is strongly related to the presence of biologic markers in the tumor. The authors propose a therapeutic approach for very young patients and for those with unfavorable biology.