Concepedia

Modeling Hepatitis B Virus X–Induced Hepatocellular Carcinoma in Mice With the Sleeping Beauty Transposon System Δ

Vincent W. Keng, Barbara R. Tschida, Jason Bell, David A. Largaespada

Hepatology · 2010 · 76 citations · 19 references

DOIFull text

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Abstract

This system can be used as a model for studying the various genetic contributions of HBV to liver hyperplasia and finally HCC in an in vivo system.

References

19

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

Yujin Hoshida, Sebastian Nijman, Masahiro Kobayashi et al. · Cancer Research · 2009 · 1.2K citations · Full text

, , +19

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

Xin Wei Wang, Kathleen Forrester, Heidi Yeh et al. · Proceedings of the National Academy of Sciences · 1994 · 662 citations · Full text

, , +16

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

Ross A. Dickins, Michael T. Hemann, Jack T. Zilfou et al. · Nature Genetics · 2005 · 523 citations

, , +7

Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice.

Markus Grompe, M al-Dhalimy, Milton J. Finegold et al. · Genes & Development · 1993 · 350 citations · Full text

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

Xin Wei Wang · Humana Press eBooks · 2003 · 321 citations