Journal of the American Chemical Society · 2008 · 269 citations · 1 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCross-coupling ReactionsHeterocycle SynthesisRetrosynthetic AnalysisAsymmetric Cross-couplingAsymmetric Heterocycle SynthesisCross-coupling CatalysisNegishi CouplingNickel-catalyzed Cross-couplingOrganozinc CompoundsOrganozinc CouplingStereoselective Cross-coupling
Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A1.
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