IN VITRO FERTILIZATION IS ASSOCIATED WITH AN INCREASED RISK OF HYPOSPADIAS

Abstract

No AccessJournal of UrologyPediatric Urology1 Jun 1999IN VITRO FERTILIZATION IS ASSOCIATED WITH AN INCREASED RISK OF HYPOSPADIAS RICHARD I. SILVER, RONALD RODRIGUEZ, THOMAS S.K. CHANG, and JOHN P. GEARHART RICHARD I. SILVERRICHARD I. SILVER , RONALD RODRIGUEZRONALD RODRIGUEZ , THOMAS S.K. CHANGTHOMAS S.K. CHANG , and JOHN P. GEARHARTJOHN P. GEARHART View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68863-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The purpose of this study was to determine if there is an increased incidence of hypospadias in male offspring conceived by in vitro fertilization (IVF). Materials and Methods: A retrospective institutional chart review from 1988 to 1992 and data from the Maryland Birth Defects Registry were statistically analyzed to assess the risk of hypospadias with IVF. Results: The data for the 5-year period indicated a 5-fold increased risk of hypospadias after IVF, with an incidence of approximately 1.5% in the IVF group and 0.3% in the control group. The only recognized difference between the groups was maternal progesterone administration in the IVF group but the cause of the increased risk of hypospadias was unknown. The distribution of hypospadias severity was similar in both groups. Conclusions: Male newborns conceived by IVF have a 5-fold increased risk of hypospadias, which may be related to maternal progesterone administration, or other maternal or fetal endocrine abnormalities that may or may not be related to infertility. Health care providers should be aware of this risk so that they can properly counsel infertile couples seeking assisted reproduction by IVF technology. References 1 : Hypospadias. In: . Philadelphia: W. B. Saunders Co.1998: 2093. chapt. 69. Google Scholar 2 : Progestins during pregnancy and hypospadias. 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Google Scholar From the Division of Pediatric Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MarylandPresented at annual meeting of American Urological Association, Orlando, Florida, May 4-9, 1996.(Silver) Current address: Division of Urology, Department of Surgery, Alfred I. duPont Hospital for Children, Wilmington, Delaware 1999.(Chang) Deceased.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByChoudhry S, Deshpande A, Qiao L, Beckman K, Sen S and Baskin L (2012) Genome-wide DNA Methylation Profiling of CpG Islands in HypospadiasJournal of Urology, VOL. 188, NO. 4S, (1450-1456), Online publication date: 1-Oct-2012.Qiao L, Tasian G, Zhang H, Cunha G and Baskin L (2018) ZEB1 is Estrogen Responsive In Vitro in Human Foreskin Cells and is Over Expressed in Penile Skin in Patients With Severe HypospadiasJournal of Urology, VOL. 185, NO. 5, (1888-1893), Online publication date: 1-May-2011.Pohl H, Joyce G, Wise M and Cilento B (2018) Cryptorchidism and HypospadiasJournal of Urology, VOL. 177, NO. 5, (1646-1651), Online publication date: 1-May-2007.Agras K, Shiroyanagi Y and Baskin L (2018) Progesterone Receptors in the Developing Genital Tubercle: Implications for the Endocrine Disruptor Hypothesis as the Etiology of HypospadiasJournal of Urology, VOL. 178, NO. 2, (722-727), Online publication date: 1-Aug-2007.Feyaerts A, Forest M, Morel Y, Mure P, Morel-Journel N, Mallet D, Nicolino M, Chatelain P, David M and Mouriquand P (2018) Endocrine Screening in 32 Consecutive Patients with HypospadiasJournal of Urology, VOL. 168, NO. 2, (720-725), Online publication date: 1-Aug-2002.FREDELL L, KOCKUM I, HANSSON E, HOLMNER S, LUNDQUIST L, LÄCKGREN G, PEDERSEN J, STENBERG A, WESTBACKE G and NORDENSKJÖLD A (2018) HEREDITY OF HYPOSPADIAS AND THE SIGNIFICANCE OF LOW BIRTH WEIGHTJournal of Urology, VOL. 167, NO. 3, (1423-1427), Online publication date: 1-Mar-2002.FISCH H, GOLDEN R, LIBERSEN G, HYUN G, MADSEN P, NEW M and HENSLE T (2018) MATERNAL AGE AS A RISK FACTOR FOR HYPOSPADIASJournal of Urology, VOL. 165, NO. 3, (934-936), Online publication date: 1-Mar-2001. Volume 161Issue 6June 1999Page: 1954-1957 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information RICHARD I. SILVER More articles by this author RONALD RODRIGUEZ More articles by this author THOMAS S.K. CHANG More articles by this author JOHN P. GEARHART More articles by this author Expand All Advertisement PDF DownloadLoading ...