A convenient synthesis of enaminones using tandem acetonitrile condensation, Grignard addition

An Efficient Stereocontrolled Strategy for the Synthesis of Hydroxyethylene Dipeptide Isosteres

Timothy L. Stuk, Anthony R. Haight, David Scarpetti et al. · The Journal of Organic Chemistry · 1994 · 46 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Regioselective route to sterically hindered cyclopropylcarbinyl halides

Robert T. Hrubiec, Michael B. Smith · The Journal of Organic Chemistry · 1984 · 43 citations

Natural Sciences, Chemistry, Drug Design +5

A novel synthetic approach to steroids via intramolecular 1,3-dipolar cycloaddition. A highly stereocontrolled synthesis of testosterone

Masataka Ihara, Yuji Tokunaga, Keiichiro Fukumoto · The Journal of Organic Chemistry · 1990 · 35 citations

Life Sciences, Endocrinology, Medicinal Chemistry +8

Dipeptide isosteres. 2. Synthesis of hydroxyethylene dipeptide isostere diastereomers from a common γ-lactone intermediate. Preparation of renin and HIV-1 protease inhibitor transition state mimics.

William R. Baker, John K. Pratt · Tetrahedron · 1993 · 34 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Synthesis of a novel C2-symmetrical (2S,5S)-2,5-bis-[(1,1-dimethylethoxy)carbonylamino]-1,6-diphenylhex-3-ene: Applications in the synthesis of potential HIV protease inhibitors

AV Rama Rao, Mukund K. Gurjar, Shashwati Pal et al. · Tetrahedron Letters · 1995 · 19 citations

Pharmacy, Chemistry, Medicinal Chemistry +12