New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

François Hyafil, Catherine Vergely, Philippe Vignaud et al. · PubMed · 1993 · 529 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

Gwenaëlle Conseil, Helene Baubichon-Cortay, Guila Dayan et al. · Proceedings of the National Academy of Sciences · 1998 · 379 citations

Medicine, Biochemistry, Pharmacology +12

Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.

Anil K. Tyagi, Rana P. Singh, Chapla Agarwal et al. · PubMed · 2002 · 328 citations

Medicine, Oncology, Pharmacology +13

Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport

Shuzhong Zhang, Marilyn E. Morris · Journal of Pharmacology and Experimental Therapeutics · 2003 · 310 citations

Medicine, Oncology, Pharmacology +16

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

Sunil K. Manna, Asok Mukhopadhyay, Nguyen Thanh Van et al. · PubMed · 1999 · 293 citations

Life Sciences, Cell Biology, Immunology +15