Synthesis of tritium‐labelled natural prostaglandins of series 1,2,3

Abstract

Abstract The complete chemical synthesis of unsaturated precursors of eicosanoids of series 1,2,3 is described. Selective hydrogenation by gaseous tritium of eicosapolyenoic acid acetylenic analogues was used to introduce the label into dihomo‐α‐linolenic, arachidonic and timnodonic acids, from which [ 3 H]PGE, [ 3 H]PGD and [ 3 H]TXB 2 were obtained by biosynthesis. From [ 3 H]PGE multiply labelled PGA, PGB, PGF α , PGI 2 ME, 6‐keto‐PGF 1α ME were synthesized by chemical methods.