The Mouse Atherosclerosis Locus at Chromosome 10 ( <i>Ath11</i> ) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions

Abstract

Ath11 appears to act early in lesion formation, with significant effects on aortic gene expression. This quantitative trait locus is genetically complex, containing a female-specific region 10a from 0 to 7.3 megabases (21 genes) and a gender-independent region 10b from 20.1 to 21.9 megabases (7 genes).