Concepedia

Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of dabigatran etexilate, intermediate metabolite and dabigatran in 50μL rat plasma and its application to pharmacokinetic study

LI Jin-yin, Jing Fang, Fanyi Zhong, Wenxue Li, Yungen Xu, Shilong Mao, Guorong Fan

Journal of Chromatography B · 2014 · 21 citations · 19 references

DOI

Concepts

References

19

Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS

B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng · Analytical Chemistry · 2003 · 5.2K citations

, , +17

The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds

Ryan P. Bonfiglio, Richard C. King, Timothy Olah et al. · Rapid Communications in Mass Spectrometry · 1999 · 922 citations

, , +10

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

Joachim Stangier, Karin Rathgen, Hildegard Stähle et al. · British Journal of Clinical Pharmacology · 2007 · 884 citations · Full text

, , +17

Influence of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate

Joachim Stangier, Karin Rathgen, Hildegard Stähle et al. · Clinical Pharmacokinetics · 2010 · 722 citations

, , +13

The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans

Stefan Blech, Thomas Ebner, Eva Ludwig-Schwellinger et al. · Drug Metabolism and Disposition · 2007 · 682 citations

, , +14