Synthesis of β-Halo-pyrrolidinones through a Tandem Sequence of 5-Endo Halolactamization and C–H Oxidative Functionalization

Abstract

A tandem sequence of 5-endo halolactamization and direct C-H oxidative functionalization is described. A range of β-halo-pyrrolidinones can be efficiently synthesized using this method, making it an excellent approach for constructing natural products containing pyrrolidinones.