Serum Vanadium Levels in Chronic Renal Disease

Abstract

Brief Reports1 November 1979Serum Vanadium Levels in Chronic Renal DiseaseELSA N. BELLO-REUSS, M.D., TIMOTHY P. GRADY, B.S., DEBESH C. MAZUMDAR, M.B., B.S.ELSA N. BELLO-REUSS, M.D., TIMOTHY P. GRADY, B.S., DEBESH C. MAZUMDAR, M.B., B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-743 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with progressive renal failure maintain sodium balance by excreting a higher fraction of the filtered load of sodium (1). Although the mechanisms responsible for the increase in fractional sodium excretion are not completely understood, a number of studies suggest that an inhibitor(s) of sodium transport is present in the serum and urine from patients with chronic renal failure (2, 3). Recently, it has been shown that sodium vanadate, an inhibitor of (Na+, K+)-activated adenosine triphosphatase, has a potent natriuretic effect in the rat (4, 5). Because vanadium is a naturally occurring trace element and is excreted by the kidney,...References1. BRICKER N, BOURGOIGNIE J, and WEBER H. The renal response to progressive nephron loss. In: BRENNER BM, RECTOR FC, eds. The Kidney. Philadelphia: WB Saunders Co.; 1976: 703-36. Google Scholar2. BOURGOIGNIE J, HWANG K, ESPINEL C, KLAHR S, and BRICKER N. A natriuretic factor in the serum of patients with chronic uremia. J Clin Invest. 1972;51:1515-27. CrossrefGoogle Scholar3. FINE L, BOURGOIGNIE J, HWANG K, and BRICKER N. On the influence of the natriuretic factor from the urine of patients with chronic uremia on bioelectric properties and sodium transport of the isolated mammalian collecting tubule. J Clin Invest. 1976;58:590-7. CrossrefMedlineGoogle Scholar4. JOSEPHSON L and CANTLEY L Isolation of a potent (Na-K) ATPase inhibitor from striated muscle. Biochemistry. 1977;16:4572-8. CrossrefMedlineGoogle Scholar5. BALFOUR W, GRANTHAM J, and GLYNN I. Vanadate stimulated natriuresis. Nature. 1978;275:768. CrossrefMedlineGoogle Scholar6. TIPTON I, COOK M, STEINER R, BOYE C, PERRY H, and SCHROEDER H. Trace elements in human tissue: I. Methods. Health Phys. 1963;9:89-101. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELSA N. BELLO-REUSS, M.D.; TIMOTHY P. GRADY, B.S.; DEBESH C. MAZUMDAR, M.B., B.S.Affiliations: Departments of Physiology and Nephrology Washington University School of Medicine and the Jewish Hospital of St. Louis St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of reactive oxygen species and nitric oxide in the neural control of intrarenal haemodynamics in anaesthetized normotensive ratsChronic Kidney Disease: Pathophysiology and Influence of Dietary ProteinK+ MetabolismHaematological effects of vanadium on living organismsRole of Trace Elements on Complications in Patients Undergoing Chronic HemodialysisFactors affecting the levels reported for vanadium in human serumVanadium in Chronic Hemodialysis PatientsFactors Affecting the Levels Reported for Vanadium in Human SerumHigh-performance liquid chromatographic method for the determination of vanadium in serumTrace Elements and Regular DialysisVanadate and its significance in biochemistry and pharmacologyVanadate affects glucose metabolism of human erythrocytesUraemic ToxinsTrace Metals and Regular DialysisIntestinal absorption and secretion of radioactive vanadium (48VO −3 ) in rats and effect of Al(OH) 3Vanadate increases oxygen affinity and affects enzyme activities and membrane properties of erythrocytesSpecificity of action of vanadate to the organ of cortiEffect of prolonged dietary administration of vanadate on blood pressure in the rat.Mechanism, prevention and therapy of sodium-dependent hypertensionSerum Vanadium LevelsRITA CORNELIS, PH.D., JACQUES VERSIECK, PH.D.Significance of NADH-vanadate-oxidoreductase of cardiac and erythrocyte cell membranesRegulation of active cation flux by vanadate in beating rat heart muscle cells in cultureNegative inotropic effect of vanadate in ventricular myocardium in the presence of 3-isobutyl-1-methylxanthine or isoprenalineOrgan and Metabolic Complications: Trace Elements 1 November 1979Volume 91, Issue 5Page: 743-743KeywordsAdenosine triphosphataseExcretionKidneysNatriuretic peptidesRenal diseasesRenal failureSodiumUrine ePublished: 1 December 2008 Issue Published: 1 November 1979 PDF downloadLoading ...