The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

Aimee D. Kohn, Fumito Takeuchi, Richard A. Roth · Journal of Biological Chemistry · 1996 · 474 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

Rebecca J. Griffin, Aileen M. Moloney, Mary Kelliher et al. · Journal of Neurochemistry · 2005 · 461 citations

Life Sciences, Neurobiology, Neuroscience +17

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

Laura Jaeger, Shinya Dohgu, Rukhsana Sultana et al. · Brain Behavior and Immunity · 2009 · 271 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-κB signaling pathway

Changqing Xu, Baojun Liu, Jinfeng Wu et al. · European Journal of Pharmacology · 2010 · 236 citations

Life Sciences, Immunology, Pharmacology +12

Bisperoxovanadium compounds are potent PTEN inhibitors

Annette C. Schmid, Richard Byrne, Ramón Vilar et al. · FEBS Letters · 2004 · 221 citations · Full text

Life Sciences, Oncology, Pharmacology +16