Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

Sheila L. Handley, Siddika Mithani · Naunyn-Schmiedeberg s Archives of Pharmacology · 1984 · 960 citations

Medicine, Neuroscience, Pharmacology +13

The relation between fear induced by novel stimulation and exploratory drive.

K. C. Montgomery · Journal of Comparative and Physiological Psychology · 1955 · 917 citations

Agriculture, Neuroscience, Psychology +14

Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain

Shari R. Bodnoff, Barbara E. Suranyi-Cadotte, Rémi Quirion et al. · European Journal of Pharmacology · 1987 · 97 citations

Life Sciences, Neuroscience, Pharmacology +14

Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance

Sandra E. File, Helen A. Baldwin, Kari Aranko · Brain Research Bulletin · 1987 · 64 citations

Medicine, Pharmacology, Psychiatry +14