The Journal of Organic Chemistry · 2010 · 26 citations · 36 references
PharmacyChemistryMedicinal ChemistryCarbohydrate ChemistrySynthetic Medicinal ChemistryMacrocycle SynthesisRetrosynthetic AnalysisCarbohydrate Building Block SynthesisGlycoside SynthesisLaryngeal Squamous Cell CarcinomaMacrocycle Scaffold DesignMacrocyclic Library SynthesisMacrolide GlycosidesNatural Product Total SynthesisTotal Synthesis-derived Analogues
The total synthesis of batatoside L (1), a resin glycoside possessing cytotoxicity against laryngeal carcinoma cells, has been completed in a highly convergent manner. The most crucial step in this total synthesis was the efficient construction of the 18-membered macrolactone framework through the Corey-Nicolaou macrolactonization approach.
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