MODIFICATIONS OF THE CONDITIONING REGIMEN FOR ACHIEVING MIXED CHIMERISM AND DONOR-SPECIFIC TOLERANCE IN CYNOMOLGUS MONKEYS1

Abstract

All parameters of the original preparative regimen seem to be essential for consistent success. The degree of lymphocyte depletion was proportional to the WBI dose. Long-term graft survival was observed only in recipients achieving lymphocyte chimerism of > 1.5%. In this model, lymphocyte depletion seems to be the best predictor of chimerism, and significant lymphocyte chimerism seems to be important in achieving tolerance.