A new method for the solid phase synthesis of hydroxyethylamine peptide bond isosteres : Synthesis of an HIV-1 protease inhibitor and of a β-casomorphin-5 analogue.

Solid phase synthesis of peptides containing the CH2NH peptide bond isostere

Yusuke Sasaki, David H. Coy · Peptides · 1987 · 150 citations

Natural Sciences, Biochemistry, Chemistry +14

Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease

Daniel H. Rich, Jeremy Green, Mihaly V. Toth et al. · Journal of Medicinal Chemistry · 1990 · 143 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Stereochemistry associated with the addition of 2-(trimethylsilyl)thiazole to differentially protected .alpha.-amino aldehydes. Applications toward the synthesis of amino sugars and sphingosines

Alessandro Dondoni, Giancarlo Fantin, Marco Fogagnolo et al. · The Journal of Organic Chemistry · 1990 · 130 citations

Natural Sciences, Biochemistry, Chemistry +12

Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes

Daniel H. Rich, Chong Qing Sun, J. V. N. Vara Prasad et al. · Journal of Medicinal Chemistry · 1991 · 126 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Solid phase reductive alkylation techniques in analogue peptide bond and sidechain modification

David H. Coy, Simon J. Hocart, Yusuke Sasaki · Tetrahedron · 1988 · 57 citations

Natural Sciences, Chemistry, Post-translational Modification +9