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Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

Yvonnick Loidreau, Pascal Marchand, Carole Dubouilh‐Benard, Marie‐Renée Nourrisson, Muriel Duflos, Nadège Loaëc, Laurent Meijer, Thierry Besson

European Journal of Medicinal Chemistry · 2012 · 46 citations · 31 references

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31

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Sophie Leclerc, Matthieu Garnier, Ralph Hoessel et al. · Journal of Biological Chemistry · 2001 · 719 citations · Full text

Utilization of operational schemes for analog synthesis in drug design

John G. Topliss · Journal of Medicinal Chemistry · 1972 · 452 citations

, , +21

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase

Stéphane Bach, Marie Knockaert, Jens Reinhardt et al. · Journal of Biological Chemistry · 2005 · 345 citations · Full text

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Tania Tahtouh, Jonathan M. Elkins, P. Filippakopoulos et al. · Journal of Medicinal Chemistry · 2012 · 184 citations · Full text

, , +21

Regulation of Alzheimer's disease amyloid-β formation by casein kinase I

Marc Flajolet, Gen He, Myriam Heiman et al. · Proceedings of the National Academy of Sciences · 2007 · 173 citations · Full text

, , +17