Heme Oxygenase-1 Mediated Cytoprotection Against Liver Ischemia and Reperfusion Injury: Inhibition of Type-1 Interferon Signaling

Abstract

Hepatic IRI activates TLR4 signaling in vivo to elaborate CXCL-10. HO-1 overexpression downregulates activation of STAT1 via type-1 IFN pathway downstream of TLR4, which in turn decreases CXCL-10 production. This study provides evidence for a novel mechanism by which HO-1 exerts adaptive cytoprotective and anti-inflammatory functions in the context of innate TLR4 activation.