Metal chaperones prevent zinc-mediated cognitive decline

Genetic enhancement of learning and memory in mice

Ya‐Ping Tang, Eiji Shimizu, Gilles Dubé et al. · Nature · 1999 · 1.9K citations

Life Sciences, Genetics, Neuroscience +12

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Robert A. Cherny, Craig Atwood, Michel Xilinas et al. · Neuron · 2001 · 1.5K citations · Full text

Life Sciences, Neuroscience, Pharmacology +13

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

Craig Ritchie, Ashley I. Bush, Andrew Mackinnon et al. · Archives of Neurology · 2003 · 982 citations

Life Sciences, Pharmacology, Pharmacotherapy +17

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lars Lannfelt, Kaj Blennow, Henrik Zetterberg et al. · The Lancet Neurology · 2008 · 712 citations

Medicine, Neuroscience, Pharmacology +17

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

Paul A. Adlard, Robert A. Cherny, David I. Finkelstein et al. · Neuron · 2008 · 664 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17