Verrucarin K, the First Natural Trichothecene Derivative Lacking the 12,13‐Epoxy Group. Verrucarins and Roridins. 34th Communication [1]

Abstract

Abstract A new metabolite, verrucarin K (C 27 H 34 O 8 ) has been isolated from a strain of Myrothecium verrucaria (A LBERTINI et S CHWEINITZ ) D ITMAR ex F RIES . On the basis of spectral and chemical evidence structure 1 was assigned to the new compound. Base‐catalysed hydrolysis yielded verrucarinolactone ( 5 ), E , Z ‐muconic acid ( 6 ) and trichotheca‐9, 12‐diene‐4,15‐diol ( 3 ). The implications of 1 in the trichothecane biosynthesis are discussed.