Riboflavin Lowers Homocysteine in Individuals Homozygous for the <i>MTHFR</i> 677C→T Polymorphism

Abstract

Although previously overlooked, homocysteine is highly responsive to riboflavin, specifically in individuals with the MTHFR 677 TT genotype. Our findings might explain why this common polymorphism carries an increased risk of coronary heart disease in Europe but not in North America, where riboflavin fortification has existed for >50 years.