Reduction of Overall<i>Helicobacter pylori</i>Colonization Levels in the Stomach of Mongolian Gerbil by<i>Lactobacillus johnsonii</i>La1 (LC1) and Its<i>in Vitro</i>Activities against<i>H. pylori</i>Motility and Adherence

Abstract

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.