Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics

Abstract

No clinically significant effect of gender, age, diabetes mellitus or hepatic impairment on tadalafil pharmacokinetics was observed. Renal insufficiency resulted in increased systemic exposure. Tadalafil was not associated with any serious clinically significant adverse events or study discontinuations due to adverse events.