Adaptive designs in clinical trials: why use them, and how to run and report them

Philip Pallmann, Alun Bedding, Babak Choodari‐Oskooei, +13

BMC Medicine

Tadalafil pharmacokinetics in healthy subjects

S. Thomas Forgue, Beverley Patterson, Alun Bedding, +4

British Journal of Clinical Pharmacology

INTERACTION BETWEEN THE PHOSPHODIESTERASE 5 INHIBITOR, TADALAFIL AND 2 α-BLOCKERS, DOXAZOSIN AND TAMSULOSIN IN HEALTHY NORMOTENSIVE MEN

Robert A. Kloner, Graham Jackson, Jeffrey T. Emmick, +4

The Journal of Urology

How to design a dose-finding study using the continual reassessment method

Graham Wheeler, Adrian Mander, Alun Bedding, +9

BMC Medical Research Methodology

Effect of tadalafil on cytochrome P450 3A4?mediated clearance: Studies in vitro and in vivo

Barbara J. Ring, Beverley Patterson, Murray D. Mitchell, +7

Clinical Pharmacology & Therapeutics

Clinical trial protocol for TRANSFORM‐UK: A therapeutic open‐label study of tocilizumab in the treatment of pulmonary arterial hypertension

Jules Hernández‐Sánchez, Louise Harlow, Colin Church, +7

Pulmonary Circulation

HypertensionImmunologyPathologyPharmacotherapyInflammation +23

Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics

S. Thomas Forgue, Diane L. Phillips, Alun Bedding, +5

British Journal of Clinical Pharmacology

Adaptive Design: Results of 2012 Survey on Perception and Use

Caroline Morgan, Susan Huyck, Martin Jenkins, +5

Therapeutic Innovation & Regulatory Science

Architectural DesignVisual DesignEngineeringDesign EvaluationDesign +9

Early phase clinical trials extension to guidelines for the content of statistical analysis plans

Victoria Homer, Christina Yap, Simon Bond, +16

BMJ

New ItemsClinical EndpointClinical TrialsVarious StakeholdersRandomized Controlled Trial +14

Adaptive Dose-Response Studies

Brenda Gaydos, Michael Krams, Inna Perevozskaya, +7

Drug Information Journal

Precision DosingTherapeutic Drug MonitoringToxicologyRadiation Therapy PlanningAdaptive Dose-response Studies +3