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REGULATION OF THE CELL CYCLE BY DIETHYLSTILBESTROL AND PROGESTERONE IN CULTURED ENDOMETRIAL CELLS
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1977
Year
Hormonal ContraceptiveFertilityReproductive HealthGynecologyG0 CellsCell CycleMenstrual CycleReproductive BiologyReproductive PhysiologyPublic HealthInfertilityCell DivisionEndocrinologyCell BiologyOvarian HormoneMedicineThecell CycleReproductive HormoneExtracellular Matrix
Cultures of primary explanted rabbit endometrium epithelial cellswere found to be a mixture of dividing or cycling (20%) and non-dividing orG0 (80%) cells. The addition of diethylstilbestrol had the effect of switchingmost of the G0 cells into the cell cycle and to shorten the length of thecell cycle through a shortening of G1 and S. Progesterone had the oppositeeffects.