Publication | Closed Access
Repair of DNA in Haemophilus Influenzae. II. Excision, Repair of Single-Strand Breaks, Defects in Transformation, and Host Cell Modification in UV-Sensitive Mutants
59
Citations
0
References
1968
Year
Dna DamageUv-sensitive MutantsReverse GeneticsGeneticsRadiation EffectMolecular BiologyGenome InstabilityDna ReplicationRadiation DamageGenome EditingHost Cell ModificationNatural SciencesPathogenesisHaemophilus InfluenzaeMicrobiologyUv-c IrradiationMedicineMolecular MechanismsMutagenesis
Haemophilus influenzae has been selected for a study of repair of radiation damage because with this bacterium repair of extracellularly irradiated bacteriophage DNA and transforming DNA can be investigated, as well as repair of cellular DNA. The use of seven ultraviolet (UV)-sensitive mutants (Setlow et al., 1968) with different defects in DNA repair has provided a system for assessing the biological role of some observable DNA repair processes.