Endothelial cell transfection with cationic liposomes and herpes simplex-thymidine kinase mediated killing

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Jay P. Morgenstern, Hartmut Land · Nucleic Acids Research · 1990 · 2.1K citations · Full text

Pharmacy, Pharmaceutics, Gene Delivery +15

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Sara M. Freeman, Camille N. Abboud, Katharine A. Whartenby et al. · PubMed · 1993 · 1.1K citations

Medicine, Cancer Biology, Oncology +10

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

Gary J. Nabel, E G Nabel, Zhiyong Yang et al. · Proceedings of the National Academy of Sciences · 1993 · 890 citations

Medicine, Biotechnology, Oncology +17

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

Ronald G. Crystal, Noel G. McElvaney, Melissa A. Rosenfeld et al. · Nature Genetics · 1994 · 830 citations

Medicine, Molecular Biology, Molecular Genetics +12

A Controlled Study of Adenoviral-Vector–Mediated Gene Transfer in the Nasal Epithelium of Patients with Cystic Fibrosis

Michael R. Knowles, Kathy Hohneker, Zhaoqing Zhou et al. · New England Journal of Medicine · 1995 · 568 citations · Full text

Pharmacy, Genetics, Molecular Biology +17