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The synthesis of a conformationally restrained, combined thromboxane antagonist / synthase inhibitor using an intramolecular ‘Stille’- or ‘Grigg’-palladium-catalysed cyclisation strategy

Medicinal ChemistryBiochemistryMedicineNatural SciencesCyclisation StrategyGrigg ’PharmacotherapyStereoselective SynthesisPharmacologyEnantioselective SynthesisDrug Discovery