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Effects in the Rat of Intradermal Injection of Purified Proteinases from Streptococcus and Serratia Marcescens
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1975
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Intradermal InjectionImmunologyDermatologyHypersensitivityInflammationMedical MicrobiologyInflammatory MarkerSepsisInfection ControlAntimicrobial ResistanceAcute Inflammatory ResponseSerratia ProteinaseBacterial InfectionsAutoimmune DiseaseBiochemistryAllergyClinical MicrobiologySerratia MarcescensComplement SystemAntimicrobial SusceptibilityPurified ProteinasesPathogenesisWound HealingMicrobiologyMedicinePotent Permeability Factors
Purified streptococcal proteinase and Serratia proteinase are potent permeability factors in rat skin and initiate histopathological evidence of an acute inflammatory response. These effects appear to be largely independent of terminal components of complement, histamine, and polymorphonuclear leukocytes.