Left‐Handed Helical Twists in “Mixed β‐Peptides” Derived From Alternating C‐Linked Carbo‐β³‐Amino Acids and β‐hGly Units

Abstract

Ambidextrous peptides: Novel mixed β-peptides were synthesized from alternating C-linked carbo-β3-amino acid and β-homoglycine residues. The peptides form unprecedented left-handed 10/12 and 12/10 helices (see picture) in addition to the corresponding right-handed helices.