Magnetic Resonance in Medicine · 1986 · 117 citations · 13 references
MedicineChemistryPharmacologyBiophysical ChemistryMolecular ImagingSpectroscopyMagnetic Resonance ImagingMagnetic Resonance Molecular ImagingMagnetic Resonance SpectroscopyMolecular Probe DevelopmentTargeted Imaging AgentsTargeting LigandsChelate Stability ConstantsDrug-ligand ComplexationIn Vivo Nmr SpectroscopyMagnetic Resonance Imaging Contrast AgentsMedicinal Chemistry ApplicationsMolecular Imaging Probe DesignStability ConstantsT1 Relaxation
Methods have been devised for obtaining gadolinium(III) complexes of the ligands NOTA (1,4,7-triazacyclononane-N,N',N''-triacetic acid), DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid), TETA (1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid), and DTPA (diethylenetriaminepentaacetic acid) as solids for use as pharmaceuticals. Their effectiveness as in vitro and in vivo contrast agents for NMR imaging or T1,2 relaxation agents for spectroscopy has been investigated. The Gd(DOTA) complex was shown to be a more stable alternative to Gd(DTPA) by serum stability studies and measurement of stability constants. Images of tumors grown in athymic mice were obtained by NMR after injection of Gd(DOTA) and Gd(DTPA).
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INTRAVENOUS CHELATED GADOLINIUM AS A CONTRAST AGENT IN NMR IMAGING OF CEREBRAL TUMOURS
Denis H. Carr, J. Brown, Graeme M. Bydder et al. · The Lancet · 1984 · 225 citations