B-Cell Alloantigens Determined by the H-2 Linked Ir Region Are Associated with Mixed Lymphocyte Culture Stimulation

Abstract

Cell surface antigens, controlled by genes located in the Ir region of the murine major histocompatibility complex, are shown serologically to be expressed preferentially on bone marrow-derived lymphocytes. These antigens may play a major role as stimulators in mixed lymphocyte cultures.