Dose‐effect relations of loop‐ and thiazide‐diuretics on calcium homeostasis: a randomized, double‐blinded Latin‐square multiple cross‐over study in postmenopausal osteopenic women

Abstract

Whether a LD or TD is chosen as diuretic therapy affects calcium homeostasis. The effects of LDs are potentially harmful to bone. Further studies are needed to evaluate whether long-term treatment with LDs causes osteoporosis. Until then, we suggest using, if possible, a TD rather than a LD as diuretic therapy in order not to risk deleterious effects on bone metabolism.