New Chiral 1,2‐Diamines and Their Use in Zinc‐Catalyzed Asymmetric Hydrosilylation of Acetophenone

Abstract

Abstract The preparation of two new series of chiral 1,2‐diamines and their use in the [ZnR 2 ‐diamine]‐catalyzed asymmetric hydrosilylation of acetophenone with poly(methylhydrosiloxane) (PMHS) in an aprotic medium is reported. The effect of structural modifications of the secondary diamine ligand, in particular a possible cooperative effect of two different types of chiral centers, on the N ‐benzylic side‐arms and on the ethylene bridge of the diamine skeleton, has been investigated. A new diamine ligand giving up to 91% ee is described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)