Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Pharmacy, Biotechnology, Pharmaceutics +17

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.6K citations

Life Sciences, Genetics, Immunology +17

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Alexander L. Klibanov, Kazuo Maruyama, Vladimir P. Torchilin et al. · FEBS Letters · 1990 · 2K citations · Full text

Pharmacy, Pharmaceutics, Pharmacokinetics +17

PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Manfred Ogris, Silvia Brunner, Susanne Schüller et al. · Gene Therapy · 1999 · 1.2K citations

Pharmacy, Bioengineering, Pharmaceutics +16

A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

S. Moein Moghimi, Peter Symonds, J. Clifford Murray et al. · Molecular Therapy · 2005 · 1.1K citations · Full text

Pharmacy, Pharmacology, Toxicology +17