Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

S F Wolf, Patricia A. Temple, Michiko Kobayashi et al. · The Journal of Immunology · 1991 · 856 citations

Life Sciences, Immunology, Molecular Biology +13

Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.

John P. Leonard, Matthew L. Sherman, Gerald L. Fisher et al. · PubMed · 1997 · 814 citations

Pharmacy, Immunology, Toxicology +16

Recombinant IL-12 administration induces tumor regression in association with IFN- <i>gamma</i> production.

Chet Nastala, Howard Edington, T G McKinney et al. · The Journal of Immunology · 1994 · 792 citations · Full text

Life Sciences, Immunology, Oncology +17

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.

Michael B. Atkins, Michael J. Robertson, Michael S. Gordon et al. · PubMed · 1997 · 590 citations

Medicine, Oncology, Pharmacology +15

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

Ueli Gubler, A O Chua, David S. Schoenhaut et al. · Proceedings of the National Academy of Sciences · 1991 · 584 citations

Life Sciences, Immunology, Molecular Biology +13