Synthesis of Potentially Antineoplastic Derivatives of N‐[<i>N</i>‐(2‐Chloroethyl)‐<i>N</i>‐nitrosocarbamoyl]amino Acids

Abstract

Abstract The synthesis of N ‐[ N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl]amino acids and their anilides, congeners of N ‐(2‐chloroethyl)‐ N ‐nitrosoureas, as potential antineoplastic substances is reported. N ‐[ N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl]amino acids are prepared by reaction of amino acids with N ‐(2‐chloroethyl)‐ N ‐nitrosocarbamoyl azide. Corresponding anilides and toluidides are obtained by condensation of the primary reaction products with aniline and toluidine using dicyclohexylcarbodiimide (DCC).