Synthesis of Neoglycolipids Containing Oligosaccharides Based on 3,6-Branched-α-D-Mannopyranosides as the Carbohydrate Moieties

Abstract

Abstract Several oligosaccharides containing 3,6-branched-α-D-mannopyranosides were obtained by selective glycosylation of 5-azido-3-oxapentyl α-D-mannopyranoside with acetobromosugars. After deacetylation and reduction of the spacer azido group, the oligosaccharides were coupled with the activated hemisuccinate derivatives of cholesterol and 1,2-di-O-alkylglycerol. The neoglycolipids so obtained were characterized by NMR spectroscopy and will be used as liposome coating molecules for targeting entrapped antigens. 1 Presented at the XlXIIth Infemutjonul Carbohydrate Symposium, Milan, Italy, July 21-26, 1996. Notes 1 Presented at the XlXIIth Infemutjonul Carbohydrate Symposium, Milan, Italy, July 21-26, 1996.